It could take your diabetic dog a few days – or longer – to adapt to a new dose

‍Why adjustment takes time

The body needs to rebalance‍

Insulin directly affects how your pet’s body processes glucose. If your pet has been living with high or low blood sugar for a while, their body can actually become “used” to those levels. When insulin changes, the liver, muscles, and other tissues need time to re-learn how to manage the new glucose levels.

Glucose curves shift‍

When you change the insulin dose, the timing and peak effect can also shift. It often takes a few days of monitoring to see the new blood sugar pattern and understand how your pet responds. We noticed this with Parker, particularly if we went up by half a unit.

Other factors play a role‍

Meal timing, activity level, stress, hydration, and even mild illness can all influence how quickly you see results after a dose change. When Parker was recovering from surgery, spending less time outside due to excessive heat or humidity or cold temps, we would adapt more slowly.

Here’s what we learned 

Be patient for 3–7 days before considering another insulin adjustment, unless your pet shows dangerous symptoms.

Track your pet’s appetite, energy, and behaviour, along with any home glucose readings if your vet has you monitoring. We often perform a curve after a dosage change.

Run a glucose curve after a few days on the new dose to check its effectiveness. If you can't do it yourself, schedule one with your vet.

Watch for emergency signs

If your pet shows any of these symptoms, it could indicate hypoglycemia (dangerously low blood sugar) and requires immediate veterinary attention:

• Weakness or staggering
• Trembling or twitching
• Seizures
• Extreme lethargy or collapse
• Vomiting or disorientation
  

What we learned

Yes — after an insulin adjustment, most diabetic pets need a few days to fully adapt. Patience, consistent monitoring, and close communication with your vet are the keys to keeping your furry friend safe and healthy.